For complete list of publications see: https://goo.gl/nqt7sS
Metodieva V, Marchese S, Esposito P, Danial JSH, Di Falco A, De S, Klenerman D, Varela JA. “Divergent toxicity mechanisms of amyloid-beta aggregates arising from a single aggregation reaction.” Cell Reports, 22;45(7):117595 (2026).
Resnick SJ, Qamar S, Krishna P, Korobeynikov V, Ausserwoger H, Miller A, Esposito P, Varela JA, Sheng J, Huang LH, Nixon-Abell J, Melore S, Chung CW, Läubli NF, Kapsiani S, Li X, Wang J, Zhang N, Alam MM, Burguete AS, Swayne TC, Chen Y, Liao YC, Shneider NA, Vendruscolo M, Knowles TPJ, Kaminski CF, Ruggeri FS, Kaminski-Schierle GS, St George-Hyslop P, Chavez A. “Multiplex Neurodegeneration Proteotoxicity Platform Reveals DNAJB6 Promotes non-toxic FUS Condensate Gelation and Inhibits Neurotoxicity.” Nature Communications – 16, 10285 (2025).
Watanabe A, Hirayama S, Kominato I, Marchese S, Esposito P, Metodieva V, Kimura T, Kameda H, Sano T, Takao M, Takatori S, Koike M, Varela JA, Tomita T, Murata S. “HAPLN2 forms aggregates and promotes microglial inflammation during brain aging in mice.” PLOS Biology – 23(8): e3003006 (2025).
Zepernick AL, Metodieva V, Pelegrina-Hidalgo N, Lippert AH, Horrocks MH, Varela JA. “Single-molecule imaging of aquaporin-4 array dynamics in astrocytes.” Nanoscale – 16: 9576-9582 (2024).
Rodrigues M, Bhattacharjee P, Brinkmalm A, Do DT, Pearson CM, De S, Ponjavic A, Varela JA, Kulenkampff K, Baudrexel I, Emin D, Ruggeri FS, Lee JE, Carr AR, Knowles TPJ, Zetterberg H, Snaddon TN, Gandhi S, Lee SF, Klenerman D. “Structure-specific amyloid precipitation in biofluids.” Nature Chemistry – 14: 1045–1053 (2022).
Needham LM, Weber J, Varela JA, Fyfee J, Doe DT, Xua CK, Tuttona L, Cliffe R, Keenlyside B, Klenerman D, Dobson CM, Hunter CA, Müller KH, O’Holleran K, Bohndiek SH, Snaddon TN, and Lee SF. “ThX – A next-generation probe for the early detection of amyloid aggregates”. Chemical Science – 11: 4578–4583 (2020).
De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, Vendruscolo M, and Klenerman D. “Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms”. Nature Communications, 10:1541 (2019).
Qamar S*, Wang G*, Randle S*, Ruggeri F*, Varela JA*, Lin J*, Phillips E*, Miyashita A, Williams G, Strohl F, Meadows W, Ferry R, Dardov V, Tartaglia G, Farrer L, Kaminski Schierle G, Kaminski C, Holt C, Fraser P, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P. “FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions”. Cell, 720–734 (2018).
Varela JA, Rodrigues M, De S, Flagemeier P, Dobson CM, Klenerman D, Lee SF. “Optical structural analysis of individual α-synuclein oligomers”. Angewandte Chemie International Edition, 4886–4890 (2018).
Danné N, Godin A, Gao Z, Varela JA, Groc L, Lounis B, Cognet L. “Comparative analysis of photoluminescence and up-conversion emission from individual carbon nanotubes for bio-imaging applications”. ACS Photonics, 5(2) (2018).
Godin A*, Varela JA*, Gao Z*, Danne N, Dupuis J, Lounis B, Groc L, Cognet L. “Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain”. Nature Nanotechnology, 12, 238–243 (2017).
Varela JA, Dupuis J, Etchepare L, Espana A, Cognet L and Groc L. “Targeting neurotransmitter receptors with nanoparticles in vivo allows single molecule tracking in brain tissue”. Nature Communications, 7:10947 (2016).
Varela JA*, Ferreira J*, Dupuis JP*, Durand P, Bouchet D, and Groc L. “Single nanoparticle tracking of NMDA receptors in cultured and intact brain tissue”. Neurophotonics, 3:41808 (2016).
Varela JA, Aberg C, Simpson JC, and Dawson KA. “Trajectory-Based Co-Localization Measures for Nanoparticle-Cell Interaction Studies”. Small, 11:2026–2031 (2015).
Murphy-Royal C, Dupuis JP, Varela JA*, Panatier A*, Pinson B, Baufreton J, Groc L, and Oliet SHR. “Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission”. Nature Neuroscience, 18, 219–226 (2015).
Dupuis JP, Ladépêche L, Seth H, Bard L, Varela JA, Mikasova L, Bouchet D, Rogemond V, Honnorat J, Hanse E, and Groc L. “Surface dynamics of GluN2B-NMDA receptors controls LTP of maturing glutamatergic synapses”. The EMBO Journal, 33(8), 842–61 (2014).