For complete list of publications see: https://goo.gl/nqt7sS

 

Resnick SJ, Qamar S, Krishna P, Korobeynikov V, Ausserwoger H, Miller A, Esposito P, Varela JA, Sheng J, Huang LH, Nixon-Abell J, Melore S, Chung CW, Läubli NF, Kapsiani S, Li X, Wang J, Zhang N, Alam MM, Burguete AS, Swayne TC, Chen Y, Liao YC, Shneider NA, Vendruscolo M, Knowles TPJ, Kaminski CF, Ruggeri FS, Kaminski-Schierle GS, St George-Hyslop P, Chavez A. “Multiplex Neurodegeneration Proteotoxicity Platform Reveals DNAJB6 Promotes non-toxic FUS Condensate Gelation and Inhibits Neurotoxicity.” Nature Communications –  16, 10285 (2025).

Watanabe A, Hirayama S, Kominato I, Marchese S, Esposito P, Metodieva V, Kimura T, Kameda H, Sano T, Takao M, Takatori S, Koike M, Varela JA, Tomita T, Murata S. “HAPLN2 forms aggregates and promotes microglial inflammation during brain aging in mice.” PLOS Biology – 23(8): e3003006 (2025).

Zepernick AL, Metodieva V, Pelegrina-Hidalgo N, Lippert AH, Horrocks MH, Varela JA. “Single-molecule imaging of aquaporin-4 array dynamics in astrocytes.” Nanoscale – 16: 9576-9582 (2024).

Rodrigues M, Bhattacharjee P, Brinkmalm A, Do DT, Pearson CM, De S, Ponjavic A, Varela JA, Kulenkampff K, Baudrexel I, Emin D, Ruggeri FS, Lee JE, Carr AR, Knowles TPJ, Zetterberg H, Snaddon TN, Gandhi S, Lee SF, Klenerman D. “Structure-specific amyloid precipitation in biofluids.” Nature Chemistry – 14: 1045–1053 (2022).

Needham LM, Weber J, Varela JA, Fyfee J, Doe DT, Xua CK, Tuttona L, Cliffe R, Keenlyside B,  Klenerman D, Dobson CM, Hunter CA, Müller KH, O’Holleran K, Bohndiek SH, Snaddon TN, and Lee SF. “ThX – A next-generation probe for the early detection of amyloid aggregates”. Chemical Science – 11: 4578–4583 (2020).

De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, Vendruscolo M, and Klenerman D. “Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms”. Nature Communications, 10:1541 (2019).

Qamar S*, Wang G*, Randle S*, Ruggeri F*, Varela JA*, Lin J*, Phillips E*, Miyashita A, Williams G, Strohl F, Meadows W, Ferry R, Dardov V, Tartaglia G, Farrer L, Kaminski Schierle G, Kaminski C, Holt C, Fraser P, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P. “FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions”. Cell, 720–734 (2018).

• Highlighted in: Mikhaleva and Lemke: Beyond the Transport Function of Import Receptors: What’s All the FUS about? Cell. 2018;173:549–53. 
• Covered by BBC News: https://www.bbc.co.uk/news/health-43838545

Varela JA, Rodrigues M, De S, Flagemeier P, Dobson CM, Klenerman D, Lee SF. “Optical structural analysis of individual α-synuclein oligomers”. Angewandte Chemie International Edition, 4886–4890 (2018).

Danné N, Godin A, Gao Z, Varela JA, Groc L, Lounis B, Cognet L. “Comparative analysis of photoluminescence and up-conversion emission from individual carbon nanotubes for bio-imaging applications”. ACS Photonics, 5(2) (2018).

Godin A*, Varela JA*, Gao Z*, Danne N, Dupuis J, Lounis B, Groc L, Cognet L. “Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain”. Nature Nanotechnology, 12, 238–243 (2017).       

• Editor’s Choice. Science 23 Dec 2016: Vol. 354, Issue 6319, pp. 1547

Aberg C*, Varela JA*, Fitzpatrick LW, and Dawson KA. “Spatial and Structural Metrics for Living Cells Inspired by Statistical Mechanics”. Scientific Reports, 6:34457 (2016).

Varela JA, Dupuis J, Etchepare L, Espana A, Cognet L and Groc L. “Targeting neurotransmitter receptors with nanoparticles in vivo allows single molecule tracking in brain tissue”. Nature Communications, 7:10947 (2016).

Gao Z, Varela JA, Groc L, Lounis B, Cognet L. “Toward the suppression of cellular toxicity from single-walled carbon nanotubes”. Biomaterirals Science, 4, 230–44 (2016).

Varela JA*, Ferreira J*, Dupuis JP*, Durand P, Bouchet D, and Groc L. “Single nanoparticle tracking of NMDA receptors in cultured and intact brain tissue”. Neurophotonics, 3:41808 (2016).

Varela JA, Dupuis J, Groc L. “Single nanoparticle tracking of surface ion channels and receptors in brain cells”. Neuromethods, 110, 49-58 (2016).

Varela JA, Aberg C, Simpson JC, and Dawson KA. “Trajectory-Based Co-Localization Measures for Nanoparticle-Cell Interaction Studies”. Small, 11:2026–2031 (2015).

Murphy-Royal C, Dupuis JP, Varela JA*, Panatier A*, Pinson B, Baufreton J, Groc L, and Oliet SHR. “Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission”. Nature Neuroscience, 18, 219–226 (2015).

• Journal Cover. Highlighted in: Edwards RH. Nature Neuroscience, 18:166–168 (2015).

Dupuis JP, Ladépêche L, Seth H, Bard L, Varela JA, Mikasova L, Bouchet D, Rogemond V, Honnorat J, Hanse E, and Groc L. “Surface dynamics of GluN2B-NMDA receptors controls LTP of maturing glutamatergic synapses”. The EMBO Journal, 33(8), 842–61 (2014).

• Journal Cover. Highlighted in: Matt L, Hell JW. The EMBO Journal, 33:781–782 (2014). 

Genin E, Gao Z*, Varela JA*, Daniel J*, Bsaibess T, Gosse I, Groc L, Cognet L and Blanchard-Desce M. “«Hyper-bright» Near-Infrared Emitting Fluorescent Organic Nanoparticles for Single Particle Tracking”. Advanced Materials, 26(14), 2258–61, 2257 (2014).

Varela JA, Bexiga MG, Aberg C, Simpson JC and Dawson KA. “Quantifying size-dependent interactions between fluorescently-labeled polystyrene nanoparticles and mammalian cells”. Journal of Nanobiotechnology, 10:39 (2012).

Dos Santos T, Varela JA, Lynch I, Salvati A and Dawson KA. “Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines”. PloS ONE, 6: e24438 (2011).

Salvati A, Aberg C, dos Santos T, Varela JA, Pinto P, Lynch I and Dawson KA. “Experimental and theoretical comparison of intracellular import of polymeric nanoparticles and small molecules: toward models of uptake kinetics”. Nanomedicine : nanotechnology, biology, and medicine, 7: 818-26 (2011).

Dos Santos T, Varela JA, Lynch I, Salvati A and Dawson KA. “Quantitative assessment of the comparative nanoparticle-uptake efficiency of a range of cell lines”. Small, 7: 3341-9 (2011). 

Bexiga MG, Varela JA, Wang F, Fenaroli F, Salvati A, Lynch I, Simpson JC and Dawson KA. “Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line”. Nanotoxicology, 5: 557-567 (2010).

Cabeza C, Varela JA, Bove I, Freire D, Martí AC, Sarasúa LG, Usera G, Montagne R and Araujo M. “Two-layer stratified flows over pronounced obstacles at low-to-intermediate Froude numbers”. Physics of Fluids, 21: 044102 (2009).

Varela JA, Araujo M, Bove I, Cabeza C, Usera G, Marti A, Montagne R and Sarasua L. “Instabilities developed in stratified flows over pronounced obstacles”. Physica A: Statistical Mechanics and its Applications, 386: 681-685 (2007).